Last update :
15/10/2021
References   References 4600  
Type : Journal
Web link : http://dx.doi.org/10.1097/OP9.0000000000000032

Research teams : Nancy - University Hospital of Nancy, Department of Pharmacy
Authors : Loeuille G, Vigneron J, D’Huart E, Demoré B.
Title : Physicochemical stability of lurbinectedin reconstituted at 500 µg/mL and diluted at 15, 30, and 70 µg/mL in 0.9% sodium chloride and 5% dextrose.
Reference : EJOP ; 4: 3. 2021

Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 

List of drugs
InjectionLurbinectedin Anticancer drug
Stability in solutions Glass Water for Injection 500 µg/ml 2-8°C Protect from light
14 Day
Stability in solutions Glass NaCl 0,9% or Glucose 5% 15 µg/ml 2-8°C Protect from light
14 Day
Stability in solutions Glass NaCl 0,9% or Glucose 5% 70 µg/ml 2-8°C Protect from light
14 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 30 µg/ml 2-8°C Protect from light
14 Day

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