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References   References 4590  
Type : Journal
Web link : https://doi.org/10.1002/jppr.1746
Research teams : Brisbane - Queensland Children's Hospital
Authors : Smith E.K, McWhinney MPhil B.C.
Title : Stability of buffered benzylpenicillin and flucloxacillin for a paediatric outpatient parenteral antibiotic therapy service.
Reference : J Pediatr Pharmacol Ther ; 51: 231-237. 2021
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionFlucloxacillin sodium Antibiotic
Stability in solutions Polyisoprene elastomer NaCl 0.9% citrate buffer 0.3% pH7 5 & 60 mg/ml 2-8°C Protect from light
6 Day
Stability in solutions Polyisoprene elastomer NaCl 0.9% citrate buffer 0.3% pH7 5 & 60 mg/ml 37°C Protect from light
24 Hour
injectionPenicillin G sodium Antibiotic
Stability in solutions Polyisoprene elastomer NaCl 0.9% citrate buffer 0.3% pH7 0.025 & 0.1 MUI/ml 2-8°C Protect from light
6 Day
Stability in solutions Polyisoprene elastomer NaCl 0.9% citrate buffer 0.3% pH7 0.025 & 0.1 MUI/ml 37°C Protect from light
24 Hour
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