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References   References 4559  
Type : Journal
Research teams : Wuhan - Wuhan University, College of Pharmacy
Authors : Chen P, Chen F, Lei J, Zhou B.
Title : Physical Compatibility and Chemical Stability of Fentanyl and Naloxone Hydrochloride in 0.9% Sodium Chloride Injection Solution for Patient-Controlled Analgesia Administration.
Reference : Drug Design Dev Ther ;14, 4179-4187. 2020
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionFentanyl citrate Analgesic
injectionNaloxone hydrochloride Antidote
Stability of mixtures
Glass Sodium chloride 0,9% 25°C Protect from light
injection Fentanyl citrate 20 µg/ml
injection Naloxone hydrochloride 0,004 mg/ml
72 Hour
Glass Sodium chloride 0,9% 4°C Protect from light
injection Fentanyl citrate 20 µg/ml
injection Naloxone hydrochloride 0,004 mg/ml
72 Hour
Polyvinyl chloride Sodium chloride 0,9% 25°C Protect from light
injection Fentanyl citrate 20 µg/ml
injection Naloxone hydrochloride 0,004 mg/ml
72 Hour
Polyvinyl chloride Sodium chloride 0,9% 4°C Protect from light
injection Fentanyl citrate 20 µg/ml
injection Naloxone hydrochloride 0,004 mg/ml
72 Hour
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