Last update :
19/04/2021
References   References 4512  
Type : Journal

Research teams : Birmingham - Queen Elisabeth Hospital, Pharmacy Department
Authors : Jamieson C,Ozolina L,Seaton RA, Gilchrist M, Hills T, Drummond F, Wilkinson AS.
Title : Assessment of the stability of citrate- buffered piperacillin/tazobactam for continuous infusion when stored in two commercially available elastomeric devices for outpatient parenteral antimicrobial chemotherapy: a study compliant with the NHS Yellow Cover Document requirements
Reference : EJHP 2020;0:1-5. 2020

Level of Evidence : 
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionPiperacillin sodium / tazobactam Antibiotic
Stability in solutions Elastomer NaCl 0.9% citrate buffer 0.3% pH7 25 mg/ml 2-8°C Not specified
13 Day
Stability in solutions Elastomer NaCl 0.9% citrate buffer 0.3% pH7 25 mg/ml 32°C Not specified
24 Hour
Stability in solutions Elastomer NaCl 0.9% citrate buffer 0.3% pH7 90 mg/ml 2-8°C Not specified
13 Day
Stability in solutions Elastomer NaCl 0.9% citrate buffer 0.3% pH7 90 mg/ml 32°C Not specified
24 Hour

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