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References   References 4505  
Type : Journal
Web link : https://doi.org/10.1016/j.ejca.2020.04.042
Research teams : Créteil - Henri Mondor University Hospital, Department of Pharmacy
Authors : Le Guyader G, Vieillard V, Mouraud S, Do B, Marabelle A, Paul M.
Title : Stability of nivolumab in its original vials after opening and handing in normal saline bag for intravenous infusion.
Reference : Eur J Cancer ; 135: 192-202. 2020
Level of Evidence : 
Level of evidence A+
Physical stability : 
Protein: Size Exclusion Chromatography Protein: Dynamic Light Scattering 
Chemical stability : 
Protein: ultraviolet spectrometry and second derivative
Protein: ionic chromatography
Other methods : 
PH measurement Protein: biological activity 
Comments : 
List of drugs
injectionNivolumab Anticancer drug
Stability in solutions Glass None 10 mg/ml 40°C Not specified
7 Day
Stability in solutions partially used vials None 10 mg/ml 2-8°C Not specified
28 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 2 mg/ml 2-8°C Not specified
28 Day
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