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References   References 4407  
Type : Journal
Web link : https://doi.org/10.1093/ajhp/zxaa025
Research teams : Philadelphia - Thomas Jefferson University Hospital, Department of Pharmacy
Authors : Bustin A, Ramsey Z, Hanna B, Kaushal G.
Title : Compatibility of treprostinil sodium and dopamine hydrochloride during simulated Y-site administration.
Reference : Am J Health-Syst Pharm ;77,8:649–657. 2020
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
List of drugs
InjectionDopamine hydrochloride Cardiotonic
Compatible 0,6 mg/ml + InjectionTreprostinil 0,5 mg/ml + NaCl 0,45% Glucose 2,5%
Compatible 0,6 >> 40 mg/ml + InjectionTreprostinil 0,004 >>0,076 mg/ml + NaCl 0,45% Glucose 2,5%
Incompatible 3,2 mg/ml + InjectionTreprostinil 0,5 mg/ml + NaCl 0,45% Glucose 2,5%
Incompatible 6 mg/ml + InjectionTreprostinil 0,5 mg/ml + NaCl 0,45% Glucose 2,5%
Incompatible 40 mg/ml + InjectionTreprostinil 0,5 mg/ml + NaCl 0,45% Glucose 2,5%
InjectionTreprostinil Vasodilator
Compatible 0,5 mg/ml + InjectionDopamine hydrochloride 0,6 mg/ml + NaCl 0,45% Glucose 2,5%
Compatible 0,004 >>0,076 mg/ml + InjectionDopamine hydrochloride 0,6 >> 40 mg/ml + NaCl 0,45% Glucose 2,5%
Incompatible 0,5 mg/ml + InjectionDopamine hydrochloride 3,2 mg/ml + NaCl 0,45% Glucose 2,5%
Incompatible 0,5 mg/ml + InjectionDopamine hydrochloride 6 mg/ml + NaCl 0,45% Glucose 2,5%
Incompatible 0,5 mg/ml + InjectionDopamine hydrochloride 40 mg/ml + NaCl 0,45% Glucose 2,5%
Stability of mixtures
Glass NaCl 0,45% Glucose 2,5% 25°C Not specified
Injection Treprostinil 0,004 >>0,076 mg/ml
Injection Dopamine hydrochloride 0,6 >> 40 mg/ml
4 Hour
Glass NaCl 0,45% Glucose 2,5% 25°C Not specified
Injection Treprostinil 0,5 mg/ml
Injection Dopamine hydrochloride 0,6 mg/ml
4 Hour
  Mentions Légales