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References   References 4350  
Type : Journal
Research teams : Nancy - University Hospital of Nancy, Department of Pharmacy
Authors : Beiler B, Barraud D, Vigneron J, Demor? B.
Title : Physicochemical stability of an admixture of lidocaine and ketamine in polypropylene syringe used in opioid-free anaesthesia.
Reference : EJHP ;0:1-5 2019
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionKetamine hydrochloride General anesthetic
Compatible 2.5 mg/ml + injectionLidocaine hydrochloride 20 mg/ml + Sodium chloride 0,9%
injectionLidocaine hydrochloride Local anesthetic
Compatible 20 mg/ml + injectionKetamine hydrochloride 2.5 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polypropylen Syringe Sodium chloride 0,9% 28°C Protect from light
injection Lidocaine hydrochloride 20 mg/ml
injection Ketamine hydrochloride 2,5 mg/ml
48 Hour
  Mentions Légales