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References   References 4250  
Type : Journal
Icone.pdf
415Ko
Research teams : Nancy - University Hospital of Nancy, Department of Pharmacy
Authors : D'Huart E, Vigneron J, Clarot I, Demoré B.
Title : Physicochemical stability of norepinephrine bitartrate in polypropylene syringes at high concentrations for intensive care units.
Reference : Ann Pharm Fr ;77,3:212-221. 2019
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionNorepinephrine bitartrate Sympathomimetic
Stability in solutions Polypropylen Syringe Glucose 5% 0,5 mg/ml 20-25°C With or without light
48 Hour
Stability in solutions Polypropylen Syringe Glucose 5% 1,16 mg/ml 20-25°C With or without light
48 Hour
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