Last update :
19/11/2024
References   References 4248  
Type : Journal
Web link : https://doi.org/10.1177/0018578719836649

Research teams : Mont Godinne - Drug Stability Research Group (DSRG) - CHU UCL NAMUR, site de Godinne
Authors : Colsoul M.L, Breuer A, Goderniaux N, Hecq J.D, Soumoy L, Bihin B, Jamart J, Galanti L.
Title : Long-Term Stability of Lorazepam in Sodium Chloride 0.9% Stored at Different Temperatures in Different Containers.
Reference : Hosp Pharm ; 55, 3: 199-193. 2019

Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Microscopic examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
injectionLorazepam Anxiolytic
Stability in solutions Glass Sodium chloride 0,9% 0,167 mg/ml 2-8°C Not specified
1 Day
Stability in solutions Glass Sodium chloride 0,9% 0,167 mg/ml 20-25°C Not specified
1 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 0,167 mg/ml 2-8°C Not specified
2 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 0,167 mg/ml 20-25°C Not specified
4 Day

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