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References   References 421  
Type : Journal
Research teams : Salt Lake City - University of Utah Health Care, Department of Pharmacy Services
Authors : Foley PT, Bosso JA, Bair JN, Townsend RJ.
Title : Compatibility of clindamycin phosphate with cefotaxim sodium or netilmicin sulfate in small-volume admixtures.
Reference : Am J Hosp Pharm ; 42: 839-843. 1985
Level of Evidence : 
Joker
Level of Evidence : 
Level of evidence A Cefotaxime sodium
Biological analysis Netilmicin sulfate
Level of evidence A Clindamycin phosphate
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Degradation products not observed in real conditions
Stability indicating capability inadequately assessed
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
List of drugs
InjectionCefotaxime sodium Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 20 mg/ml 24°C Light
24 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 20 mg/ml 24°C Light
24 Hour
Compatible 20 mg/ml + InjectionClindamycin phosphate 9 mg/ml + NaCl 0,9% or Glucose 5%
InjectionClindamycin phosphate Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 9 mg/ml 24°C Light
24 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 9 mg/ml 24°C Light
24 Hour
Compatible 9 mg/ml + InjectionCefotaxime sodium 20 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 9 mg/ml + InjectionNetilmicin sulfate 3 mg/ml + NaCl 0,9% or Glucose 5%
InjectionNetilmicin sulfate Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 3 mg/ml 24°C Light
24 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 3 mg/ml 24°C Light
24 Hour
Compatible 3 mg/ml + InjectionClindamycin phosphate 9 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Glass NaCl 0,9% or Glucose 5% 24°C Light
Injection Clindamycin phosphate 9 mg/ml
Injection Cefotaxime sodium 20 mg/ml
24 Hour
Glass NaCl 0,9% or Glucose 5% 24°C Light
Injection Clindamycin phosphate 9 mg/ml
Injection Netilmicin sulfate 3 mg/ml
24 Hour
Polyvinyl chloride NaCl 0,9% or Glucose 5% 24°C Light
Injection Clindamycin phosphate 9 mg/ml
Injection Cefotaxime sodium 20 mg/ml
24 Hour
Polyvinyl chloride NaCl 0,9% or Glucose 5% 24°C Light
Injection Clindamycin phosphate 9 mg/ml
Injection Netilmicin sulfate 3 mg/ml
24 Hour
  Mentions Légales