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References   References 4180  
Type : Journal
Web link : https://doi.org/10.3747/pdi.2017.00274
Research teams : Hobart - University of Tasmania, School of Pharmacy
Authors : Mendes K, Harmanjeet H, Sedeeq M, Modi A, Wanandy T, Zaidi S, Ming L, Castelino R, Sud K, Peterson G, Patel R.
Title : Stability of meropenem and piperacillin/tazobactam with heparin in various peritoneal dialysis solutions.
Reference : Perit Dial Int ;38,6:430-440 2018
Level of Evidence : 
Level of evidence B
Physical stability : 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
Comments : 
List of drugs
InjectionHeparin sodium Anticoagulant
Compatible 0.5 UI/ml + InjectionMeropenem 0.5 mg/ml + Dianéal® 1.5% glucose (Baxter)
Compatible 0.5 UI/ml + InjectionMeropenem 0.5 mg/ml + Extraneal® (Baxter)
Compatible 0.5 UI/ml + InjectionMeropenem 0.5 mg/ml + Dianéal® 2.5% glucose (Baxter)
Compatible 0.5 UI/ml + InjectionMeropenem 0.5 mg/ml + Dianéal® 4.25% glucose (Baxter)
Compatible 0.5 UI/ml + InjectionPiperacillin sodium / tazobactam 0.5/0.0625 mg/ml + Extraneal® (Baxter)
Compatible 1.4 UI/ml + InjectionPiperacillin sodium / tazobactam 1.38/0.1725 mg/ml + Physionéal® 1.36 (Baxter)
Compatible 1.4 UI/ml + InjectionPiperacillin sodium / tazobactam 1.38/0.1725 mg/ml + Physionéal® 2.27 (Baxter)
Compatible 1.4 UI/ml + InjectionPiperacillin sodium / tazobactam 1.38/0.1725 mg/ml + Physionéal® 3.86 (Baxter)
Compatible 0.5 UI/ml + InjectionPiperacillin sodium / tazobactam 0.5/0.0625 mg/ml + Dianéal® 1.5% glucose (Baxter)
Compatible 0.5 UI/ml + InjectionPiperacillin sodium / tazobactam 0.5/0.0625 mg/ml + Dianéal® 2.5% glucose (Baxter)
Compatible 0.5 UI/ml + InjectionPiperacillin sodium / tazobactam 0.5/0.0625 mg/ml + Dianéal® 4.25% glucose (Baxter)
InjectionMeropenem Antibiotic
Compatible 0.5 mg/ml + InjectionHeparin sodium 0.5 UI/ml + Dianéal® 1.5% glucose (Baxter)
Compatible 0.5 mg/ml + InjectionHeparin sodium 0.5 UI/ml + Extraneal® (Baxter)
Compatible 0.5 mg/ml + InjectionHeparin sodium 0.5 UI/ml + Dianéal® 2.5% glucose (Baxter)
Compatible 0.5 mg/ml + InjectionHeparin sodium 0.5 UI/ml + Dianéal® 4.25% glucose (Baxter)
InjectionPiperacillin sodium / tazobactam Antibiotic
Compatible 0.5/0.0625 mg/ml + InjectionHeparin sodium 0.5 UI/ml + Extraneal® (Baxter)
Compatible 1.38/0.1725 mg/ml + InjectionHeparin sodium 1.4 UI/ml + Physionéal® 1.36 (Baxter)
Compatible 1.38/0.1725 mg/ml + InjectionHeparin sodium 1.4 UI/ml + Physionéal® 2.27 (Baxter)
Compatible 1.38/0.1725 mg/ml + InjectionHeparin sodium 1.4 UI/ml + Physionéal® 3.86 (Baxter)
Compatible 0.5/0.0625 mg/ml + InjectionHeparin sodium 0.5 UI/ml + Dianéal® 1.5% glucose (Baxter)
Compatible 0.5/0.0625 mg/ml + InjectionHeparin sodium 0.5 UI/ml + Dianéal® 2.5% glucose (Baxter)
Compatible 0.5/0.0625 mg/ml + InjectionHeparin sodium 0.5 UI/ml + Dianéal® 4.25% glucose (Baxter)
Stability of mixtures
Polyvinyl chloride Dianéal® PD1 1.5% glucose (Baxter) 37°C Not specified
Injection Piperacillin sodium / tazobactam 0,5/0,0625 mg/ml
Injection Heparin sodium 0,5 UI/ml
10 Hour
Polyvinyl chloride Dianéal® PD1 1.5% glucose (Baxter) 37°C Not specified
Injection Meropenem 0,5 mg/ml
Injection Heparin sodium 0,5 UI/ml
10 Hour
Polyvinyl chloride Dianéal® PD1 1.5% glucose (Baxter) 4°C Not specified
Injection Piperacillin sodium / tazobactam 0,5/0,0625 mg/ml
Injection Heparin sodium 0,5 UI/ml
168 Hour
Polyvinyl chloride Dianéal® PD1 1.5% glucose (Baxter) 4°C Not specified
Injection Meropenem 0,5 mg/ml
Injection Heparin sodium 0,5 UI/ml
168 Hour
Polyvinyl chloride Dianéal® PD2 4.25% glucose (Baxter) 37°C Not specified
Injection Piperacillin sodium / tazobactam 0,5/0,0625 mg/ml
Injection Heparin sodium 0,5 UI/ml
10 Hour
Polyvinyl chloride Dianéal® PD2 4.25% glucose (Baxter) 37°C Not specified
Injection Meropenem 0,5 mg/ml
Injection Heparin sodium 0,5 UI/ml
10 Hour
Polyvinyl chloride Dianéal® PD2 4.25% glucose (Baxter) 4°C Not specified
Injection Piperacillin sodium / tazobactam 0,5/0,0625 mg/ml
Injection Heparin sodium 0,5 UI/ml
168 Hour
Polyvinyl chloride Dianéal® PD2 4.25% glucose (Baxter) 4°C Not specified
Injection Meropenem 0,5 mg/ml
Injection Heparin sodium 0,5 UI/ml
168 Hour
Polyvinyl chloride Dianéal® PD2 2.5% glucose (Baxter) 37°C Not specified
Injection Piperacillin sodium / tazobactam 0,5/0,0625 mg/ml
Injection Heparin sodium 0,5 UI/ml
10 Hour
Polyvinyl chloride Dianéal® PD2 2.5% glucose (Baxter) 37°C Not specified
Injection Meropenem 0,5 mg/ml
Injection Heparin sodium 0,5 UI/ml
10 Hour
Polyvinyl chloride Dianéal® PD2 2.5% glucose (Baxter) 4°C Not specified
Injection Piperacillin sodium / tazobactam 0,5/0,0625 mg/ml
Injection Heparin sodium 0,5 UI/ml
168 Hour
Polyvinyl chloride Dianéal® PD2 2.5% glucose (Baxter) 4°C Not specified
Injection Meropenem 0,5 mg/ml
Injection Heparin sodium 0,5 UI/ml
168 Hour
Polyvinyl chloride Extraneal® (Baxter) 37°C Not specified
Injection Piperacillin sodium / tazobactam 0,5/0,0625 mg/ml
Injection Heparin sodium 0,5 UI/ml
10 Hour
Polyvinyl chloride Extraneal® (Baxter) 37°C Not specified
Injection Meropenem 0,5 mg/ml
Injection Heparin sodium 0,5 UI/ml
10 Hour
Polyvinyl chloride Extraneal® (Baxter) 4°C Not specified
Injection Piperacillin sodium / tazobactam 0,5/0,0625 mg/ml
Injection Heparin sodium 0,5 UI/ml
168 Hour
Polyvinyl chloride Extraneal® (Baxter) 4°C Not specified
Injection Meropenem 0,5 mg/ml
Injection Heparin sodium 0,5 UI/ml
168 Hour
Polyvinyl chloride Physionéal® 1.36 (Baxter) 37°C Not specified
Injection Piperacillin sodium / tazobactam 1,38/0,172 mg/ml
Injection Heparin sodium 1,4 UI/ml
10 Hour
Polyvinyl chloride Physionéal® 1.36 (Baxter) 4°C Not specified
Injection Piperacillin sodium / tazobactam 1,38/0,172 mg/ml
Injection Heparin sodium 1,4 UI/ml
168 Hour
Polyvinyl chloride Physionéal® 2.27 (Baxter) 37°C Not specified
Injection Piperacillin sodium / tazobactam 1,38/0,172 mg/ml
Injection Heparin sodium 1,4 UI/ml
10 Hour
Polyvinyl chloride Physionéal® 2.27 (Baxter) 4°C Not specified
Injection Piperacillin sodium / tazobactam 1,38/0,172 mg/ml
Injection Heparin sodium 1,4 UI/ml
168 Hour
Polyvinyl chloride Physionéal® 3.86 (Baxter) 37°C Not specified
Injection Piperacillin sodium / tazobactam 1,38/0,172 mg/ml
Injection Heparin sodium 1,4 UI/ml
10 Hour
Polyvinyl chloride Physionéal® 3.86 (Baxter) 4°C Not specified
Injection Piperacillin sodium / tazobactam 1,38/0,172 mg/ml
Injection Heparin sodium 1,4 UI/ml
168 Hour
  Mentions Légales