Last update :
03/05/2024
References   References 4143  
Type : Journal
Web link : https://ejhp.bmj.com/content/25/4/214

Research teams : Rouen - Department of Pharmacy, Cancer Centre Henri Becquerel, Rouen, France.
Authors : Daouphars M, Hervou?t C.H, Bohn P, Martin D, Rouvet J, Basuyau F, Varin R.
Title : Physicochemical stability of oxycodone-ketamine solutions in polypropylene syringe and polyvinyl chloride bag for patient-controlled analgesia use.
Reference : EJHP ; 25, 4 2016

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionKetamine hydrochloride General anesthetic
Compatible 0.1 & 40 mg/ml + InjectionOxycodone hydrochloride 0.4 & 10 mg/ml + Sodium chloride 0,9%
InjectionOxycodone hydrochloride Analgesic
Compatible 0.4 & 10 mg/ml + InjectionKetamine hydrochloride 0.1 & 40 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 23°C Light
Injection Ketamine hydrochloride 40 mg/ml
Injection Oxycodone hydrochloride 10 mg/ml
7 Day
Polyvinyl chloride Sodium chloride 0,9% 23°C Light
Injection Oxycodone hydrochloride 0,4 mg/ml
Injection Ketamine hydrochloride 4 mg/ml
7 Day
Polyvinyl chloride Sodium chloride 0,9% 23°C Light
Injection Ketamine hydrochloride 0,1 mg/ml
Injection Oxycodone hydrochloride 10 mg/ml
7 Day
Polypropylene Sodium chloride 0,9% 23°C Light
Injection Oxycodone hydrochloride 0,4 mg/ml
Injection Ketamine hydrochloride 4 mg/ml
7 Day
Polypropylene Sodium chloride 0,9% 23°C Light
Injection Ketamine hydrochloride 40 mg/ml
Injection Oxycodone hydrochloride 10 mg/ml
7 Day
Polypropylene Sodium chloride 0,9% 23°C Light
Injection Ketamine hydrochloride 0,1 mg/ml
Injection Oxycodone hydrochloride 10 mg/ml
7 Day

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