Last update :
29/10/2024
References   References 414  
Type : Journal
Web link : http://www.ajhp.org/content/46/12/2500.abstract

Research teams : Leiden - University Hospital Leiden, Department of clinical pharmacy and toxicology
Authors : Den Hartigh J, Brandenburg HCR, Vermeij P.
Title : Stability of azacitidine in lactated Ringer’s injection frozen in polypropylene syringes.
Reference : Am J Hosp Pharm ; 46: 2500-2505. 1989

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Degradation products identified and quantified
No visual inspection
Very unstable substance, difficult to achieve repeatability

List of drugs
injectionAzacitidine Anticancer drug
Stability in solutions Polypropylen Syringe Ringer’s lactate solution 0.5 mg/ml -20°C Protect from light
30 Day
Stability in solutions Polypropylen Syringe Ringer’s lactate solution 0.5 & 2 mg/ml 20°C Not specified
2 Hour
Stability in solutions Polypropylen Syringe Ringer’s lactate solution 2 mg/ml -20°C Protect from light
18 Day

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