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References   References 4115  
Type : Journal
Research teams : Hubei - Dongfeng Hospital, Hubei University of Medicine
Authors : Fang B, Wang L, Gu J, Chen F, Shi X.
Title : Physicochemical stability of ternary admixtures of butorphanol, ketamine, and droperidol in polyolefin bags for patient-controlled analgesia use.
Reference : Drug Design Dev Ther ;10:3873-3878 2016
Level of Evidence : 
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products not observed in real conditions
List of drugs
injectionButorphanol tartrate Analgesic
injectionDroperidol Neuroleptic
injectionKetamine hydrochloride General anesthetic
Stability of mixtures
Polyolefine Sodium chloride 0,9% 25°C Protect from light
injection Butorphanol tartrate 0,067 mg/ml
injection Ketamine hydrochloride 1,4 mg/ml
injection Droperidol 0,034 mg/ml
14 Day
Polyolefine Sodium chloride 0,9% 4°C Protect from light
injection Butorphanol tartrate 0,067 mg/ml
injection Ketamine hydrochloride 1,4 mg/ml
injection Droperidol 0,034 mg/ml
14 Day
  Mentions Légales