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References   References 4111  
Type : Journal
Research teams : Rochester - Wegmans School of Pharmacy
Authors : Camp N, Nadra J, Hughes S, Gilbert J, Zhao F.
Title : Stability of extemporaneously prepared ophtalmic solutions for mydriasis.
Reference : Am J Health-Syst Pharm ;75,9:231-235 2018
Level of Evidence : 
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
Eye-dropsCyclopentolate Various
Eye-dropsPhenylephrine hydrochloride Sympathomimetic
Eye-dropsTropicamide Antimuscarinic
Stability of mixtures
Not specified Hydrochloric acid 0,1N > pH 4.2-5.8
 2-8°C Not specified
Eye-drops Tropicamide Commercial Drug product Tropicamide USP 1% Bausch Lomb 7,5 mL
Eye-drops Phenylephrine hydrochloride Powder ® = ? 375 mg
Eye-drops Cyclopentolate Commercial Drug product Cyclopentolate USP 1% Bausch Lomb 7,5 mL
60 Day
Not specified Hydrochloric acid 0,1N > pH 4.2-5.8
 2-8°C Not specified
Eye-drops Tropicamide Commercial Drug product Tropicamide USP 1% Bausch Lomb 15 mL
Eye-drops Phenylephrine hydrochloride Powder ® = ? 375 mg
60 Day
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