Last update :
03/05/2024
References   References 411  
Type : Journal

Research teams : Winnipeg - Health Science Center, Department of Pharmaceutical Sciences
Authors : Woloschuk DMM, Wermeling JR, Pruemer JM.
Title : Stability and compatibility of fluorouracil and mannitol during simulated Y-site administration.
Reference : Am J Hosp Pharm ; 48: 2158-2160. 1991

Level of Evidence : 
Level of evidence C+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Degradation products not observed in real conditions

List of drugs
InjectionFluorouracil Anticancer drug
Compatible 1 & 2 mg/ml + InjectionMannitol 200 mg/ml + Sodium chloride 0,9%
InjectionMannitol Various
Compatible 200 mg/ml + InjectionFluorouracil 1 & 2 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polypropylen Syringe Sodium chloride 0,9% 25°C Light
Injection Fluorouracil 1 & 2 mg/ml
Injection Mannitol 200 mg/ml
24 Hour

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