Bibliographie - 4102 - Stabilis 4.0

Last update :
29/10/2024

References 4102

Type :

Journal

Research teams :

Auckland - Faculty of Medical and Health Sciences, University of Auckland

Authors :

Svirskis D, Behera S, Naidoo N, Beachman J, Raina T, Zhou Y, Berkahn L, Costello I, Gu Y.

Title :

Stability of vincristine sulfate, doxorubicin hydrochloride and etoposide phosphate admixtures in polyisoprene elastromeric pump supporting transition of the EPOCH regimen to oupatient care.

Reference :

J Oncol Pharm Practice ;25,4:831-840. 2018

Level of Evidence :

Physical stability :

Chemical stability :

High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)

Stability defined as 95% of the initial concentration

Other methods :

Comments :

List of drugs

Doxorubicin hydrochloride

Etoposide phosphate

Vincristine sulfate

2-6°C

Vincristine sulfate	0,005 mg/ml
Doxorubicin hydrochloride	0,12 mg/ml
Etoposide phosphate	0,6 mg/ml

2-6°C

Vincristine sulfate	0,01 mg/ml
Doxorubicin hydrochloride	0,24 mg/ml
Etoposide phosphate	1,2 mg/ml

2-6°C

Vincristine sulfate	0,016 mg/ml
Doxorubicin hydrochloride	0,4 mg/ml
Etoposide phosphate	2 mg/ml

35°C

Vincristine sulfate	0,005 mg/ml
Doxorubicin hydrochloride	0,12 mg/ml
Etoposide phosphate	0,6 mg/ml

35°C

Vincristine sulfate	0,01 mg/ml
Doxorubicin hydrochloride	0,24 mg/ml
Etoposide phosphate	1,2 mg/ml

35°C

Vincristine sulfate	0,016 mg/ml
Doxorubicin hydrochloride	0,4 mg/ml
Etoposide phosphate	2 mg/ml

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