Last update :
19/11/2024
References   References 4043  
Type : Journal
Web link : https://doi.org/10.1515/pthp-2017-0025

Research teams : Mainz - University Medical Center, Johannes Gutenberg
Authors : Kim S, Heeb R, Krämer I.
Title : Physicochemical Stability of Reconstituted Decitabine (Dacogen®) Solutions and Ready-to-Administer Infusion Bags when Stored Refrigerated or Frozen.
Reference : Pharmaceutical Technology in Hospital Pharmacy ;2,4: 145-157. 2017

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values

List of drugs
injectionDecitabine Anticancer drug
Stability in solutions Glass Water for Injection (4°C) 5 mg/ml 2-8°C Protect from light
12 Hour
Stability in solutions Polyolefine NaCl 0.9% (4°C) 0.5 mg/ml 2-8°C Protect from light
24 Hour
Stability in solutions syringe polycarbonate Water for Injection (4°C) 5 mg/ml -25°C Protect from light
28 Day

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