Last update :
19/11/2024
References   References 4026  
Type : Journal
Web link : http://journals.sagepub.com/doi/pdf/10.1177/0018578717721121

Research teams : Aurora - Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado
Authors : Van Matre E.T, Ho K.C., Lyda C, Fullmer B.A, Oldlan A.R, Kiser T.H.
Title : Extended Stability of Epinephrine Hydrochloride Injection in Polyvinyl Chloride Bags Stored in Amber Ultraviolet Light-Blocking Bags.
Reference : Hosp Pharm ; 52, 8 : 570-573 2017

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed

List of drugs
injectionEpinephrine hydrochloride Sympathomimetic
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 16 µg/ml 23-25°C Light
45 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 16 µg/ml 3-5°C Protect from light
60 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 64 µg/ml 23-25°C Light
45 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 64 µg/ml 3-5°C Protect from light
60 Day

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