Last update :
03/05/2024
References   References 3988  
Type : Journal
Web link : https://doi.org/10.2146/ajhp16016

Research teams : Valence - Universitat de Valencian Facultat de Quimica
Authors : Ezquer-Garin C, Ferriols-Lisart R, Al?s-Almi?ana M.
Title : Stability of tacrolimus ophthalmic solution.
Reference : Am J Health-Syst Pharm ; 74:13 : 1002-1006 2017

Level of Evidence : 
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 

List of drugs
Eye-dropsTacrolimus Immunosuppressant
Stability in solutions Plastic bottle Medicine bottle for injection 4,5 mg
Prograf®
Liquidfilm Tears® >> 15 mL
-15 & - 25°C Protect from light
85 Day
Stability in solutions Plastic bottle Medicine bottle for injection 4,5 mg
Prograf®
Liquidfilm Tears® >> 15 mL
2-8°C Protect from light
85 Day
Stability in solutions Plastic bottle Medicine bottle for injection 4,5 mg
Prograf®
Liquidfilm Tears® >> 15 mL
22-26°C Protect from light
14 Day

  Mentions Légales