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References   References 3986  
Type : Journal
Research teams : Mainz - University Medical Center, Johannes Gutenberg
Authors : Kim S, Krämer I.
Title : Physikalisch-chemische Stabilität von Carfilzomib (Kyprolis®) im Originalbehältnis nach Erstanbruch und in applikationsfertigen Zubereitungen.
Reference : Krankenhauspharmazie ;38:377-82. 2017
Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
InjectionCarfilzomib Anticancer drug
Stability in solutions Glass Water for Injection 2 mg/ml 2-8°C Not specified
28 Day
Stability in solutions Polyolefine Glucose 5% 0,6 mg/ml 2-8°C Not specified
28 Day
Stability in solutions Polyolefine Glucose 5% 0,6 mg/ml 25°C Not specified
10 Day
Stability in solutions Polypropylen Syringe Water for Injection 2 mg/ml 25°C Not specified
14 Day
Stability in solutions Polypropylen Syringe Glucose 5% 0,8 mg/ml 2-8°C Not specified
28 Day
Stability in solutions Polypropylen Syringe Glucose 5% 0,8 mg/ml 25°C Not specified
10 Day
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