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References   References 3981  
Type : Journal
Web link : http://dx.doi.org/10.1136/ejhpharm-2016-000980
Research teams : Wuhan - Wuhan University, College of Pharmacy
Authors : He G, Zeng F, Lei K, Xia S, Deng L, Zhang C, Liu D.
Title : Compatibility of dexamethasone sodium phosphate with 5-HT3 receptor antagonists in infusion solutions: a comprehensive study
Reference : EJHP ;24:162?166 2017
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
Degradation products not observed in real conditions
List of drugs
injectionAzasetron Antiemetic
Compatible 0.2 mg/ml + injectionDexamethasone sodium phosphate 0.1 & 0.2 mg/ml + Sodium chloride 0,9%
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 0.1 & 0.2 mg/ml + injectionAzasetron 0.2 mg/ml + Sodium chloride 0,9%
Compatible 0.1 & 0.2 mg/ml + injectionDolasetron mesylate 0.05 mg/ml + Sodium chloride 0,9%
Compatible 0.1 & 0.2 mg/ml + injectionDolasetron mesylate 1 mg/ml + Glucose 5%
Compatible 0.1 & 0.2 mg/ml + injectionOndansetron hydrochloride 0.08 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.1 & 0.2 mg/ml + injectionPalonosetron hydrochloride 2.5 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.1 & 0.2 mg/ml + injectionRamosetron 3 µg/ml + NaCl 0,9% or Glucose 5%
injectionDolasetron mesylate Antiemetic
Compatible 0.05 mg/ml + injectionDexamethasone sodium phosphate 0.1 & 0.2 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionDexamethasone sodium phosphate 0.1 & 0.2 mg/ml + Glucose 5%
injectionOndansetron hydrochloride Antiemetic
Compatible 0.08 mg/ml + injectionDexamethasone sodium phosphate 0.1 & 0.2 mg/ml + NaCl 0,9% or Glucose 5%
injectionPalonosetron hydrochloride Antiemetic
Compatible 2.5 µg/ml + injectionDexamethasone sodium phosphate 0.1 & 0.2 mg/ml + NaCl 0,9% or Glucose 5%
injectionRamosetron Antiemetic
Compatible 3 µg/ml + injectionDexamethasone sodium phosphate 0.1 & 0.2 mg/ml + NaCl 0,9% or Glucose 5%
injectionTropisetron hydrochloride Antiemetic
Stability of mixtures
Polyolefine NaCl 0,9% or Glucose 5% 23-27°C Light
injection Dexamethasone sodium phosphate 0,1 mg/ml
injection Ondansetron hydrochloride 0,08 mg/ml
48 Hour
Polyolefine NaCl 0,9% or Glucose 5% 23-27°C Light
injection Dexamethasone sodium phosphate 0,2 mg/ml
injection Ondansetron hydrochloride 0,08 mg/ml
48 Hour
Polyolefine NaCl 0,9% or Glucose 5% 23-27°C Light
injection Dexamethasone sodium phosphate 0,2 mg/ml
injection Palonosetron hydrochloride 2.5 µg/ml
48 Hour
Polyolefine NaCl 0,9% or Glucose 5% 23-27°C Light
injection Dexamethasone sodium phosphate 0,1 mg/ml
injection Palonosetron hydrochloride 2.5 µg/ml
48 Hour
Polyolefine NaCl 0,9% or Glucose 5% 23-27°C Light
injection Ramosetron 3 µg/ml
injection Dexamethasone sodium phosphate 0,1 mg/ml
48 Hour
Polyolefine NaCl 0,9% or Glucose 5% 23-27°C Light
injection Dexamethasone sodium phosphate 0.2 mg/ml
injection Ramosetron 3 µg/ml
48 Hour
Polyolefine Sodium chloride 0,9% 23-27°C Light
injection Dexamethasone sodium phosphate 0,2 mg/ml
injection Tropisetron hydrochloride 0,05 mg/ml
48 Hour
Polyolefine Sodium chloride 0,9% 23-27°C Light
injection Tropisetron hydrochloride 0,05 mg/ml
injection Dexamethasone sodium phosphate 0,1 mg/ml
48 Hour
Polyolefine Sodium chloride 0,9% 23-27°C Light
injection Dexamethasone sodium phosphate 0,1 mg/ml
injection Dolasetron mesylate 1 mg/ml
48 Hour
Polyolefine Sodium chloride 0,9% 23-27°C Light
injection Dexamethasone sodium phosphate 0,2 mg/ml
injection Dolasetron mesylate 1 mg/ml
48 Hour
Polyolefine Sodium chloride 0,9% 23-27°C Light
injection Azasetron 0,2 mg/ml
injection Dexamethasone sodium phosphate 0,1 mg/ml
48 Hour
Polyolefine Sodium chloride 0,9% 23-27°C Light
injection Dexamethasone sodium phosphate 0,2 mg/ml
injection Azasetron 0,2 mg/ml
48 Hour
  Mentions Légales