Last update :
18/04/2024
References   References 3977  
Type : Journal

Research teams : Villejuif - Institut Gustave Roussy, Department of Pharmacy
Authors : Desmaris R.P, Mercier L, Paci A.
Title : Stability of Melphalan in 0,9% Sodium Chloride Solutions Prepared in Polyvinyl Chloride Bags for Intravenous Injection.
Reference : Drugs R D ;15:253-259. 2015

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Thin Layer Chromatography
Other methods : 
PH measurement 
Comments : 
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point

List of drugs
InjectionMelphalan Anticancer drug
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,5 mg/ml 23-27°C Light
2 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 2 mg/ml 2-8°C Protect from light
24 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 2 mg/ml 23-27°C Light
6 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 4 mg/ml 2-8°C Protect from light
2 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 4 mg/ml 23-27°C Light
8 Hour

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