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References   References 3974  
Type : Journal
Web link : https://doi.org/10.1016/j.ejps.2019.105102
Icone.pdf
882Ko
Research teams : Lille - Faculté des Sciences Pharmaceutiques et Biologiques
Authors : Roche M, Lannoy D, Bourdon F, Dhorne C, Berneron C, Danel C, G.Fernandez, M.J,Simon N, Odou P.
Title : Stability of frozen 1% voriconazole eye drops in glass and in innovative containers.
Reference : Eur J Pharm Sci 141: 105102. 2020
Level of Evidence : 
Physical stability : 
Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement Measurement of osmolality 
Comments : 
List of drugs
Eye-dropsVoriconazole Antifungal
Stability in solutions Glass Medicine bottle for injection 100 mg
Vfend®
Water for injection >> 10 ml
-20°C Protect from light
85 Day
Stability in solutions Polyethylene Medicine bottle for injection 100 mg
Vfend®
Water for injection >> 10 mL
-20°C Protect from light
85 Day
Stability in solutions Novelia® Medicine bottle for injection 100 mg
Vfend®
Water for injection >> 10 mL
-20°C Protect from light
85 Day
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