Last update :
28/02/2024
References   References 3946  
Type : Journal
Web link : http://www.cjhp-online.ca/index.php/cjhp/article/view/1629

Research teams : Montreal - Faculté de pharmacie, Université de Montréal
Authors : Friciu M, Zaraa S, Leclair G.
Title : Stability of Extemporaneously Compounded Tacrolimus in Glass Bottles and Plastic Syringes
Reference : Can J Hosp Pharm ; 70,1 :51-53. 2017

Level of Evidence : 
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 

List of drugs
Oral solutionTacrolimus Immunosuppressant
Stability in solutions Glass Powder 15 mg
® = ?
Polysorbate 80 3,24 µl
Oral Mix® >> 30 ml
25°C Protect from light
90 Day
Stability in solutions Glass Kapseln 15 mg
Prograf®
Oral Mix® >> 30 ml
25°C Protect from light
90 Day
Stability in solutions Glass Powder 15 mg
® = ?
Polysorbate 80 3,24 µl
Oral Mix® >> 30 ml
5°C Protect from light
90 Day
Stability in solutions Glass Kapseln 15 mg
Prograf®
Oral Mix® >> 30 ml
5°C Protect from light
90 Day
Stability in solutions Syringe Powder 0,5 mg
® = ?
Polysorbate 80 1,08 µl
Oral Mix® >> 1 ml
25°C Protect from light
90 Day
Stability in solutions Syringe Kapseln 0,5 mg
Prograf®
Oral Mix® >> 1 ml
25°C Protect from light
90 Day
Stability in solutions Syringe Powder 0,5 mg
® = ?
Polysorbate 80 1.08 µl
Oral Mix® >> 1 ml
5°C Protect from light
90 Day
Stability in solutions Syringe Kapseln 0,5 mg
Prograf®
Oral Mix® >> 1 ml
5°C Protect from light
90 Day

  Mentions Légales