| Type : |
Journal |
| Web link : |
http://archive.hospital-pharmacy.com/doi/abs/10.1310/hpj5111-915 |
|
| Research teams : |
Ottawa - The Ottawa Hospital, department of Pharmacy |
| Authors : |
Donnelly R.F. |
| Title : |
Stability of Levodopa/Carbidopa Rectal Suspensions. |
| Reference : |
Hosp Pharm ; 51 ; 11 : 915-921. 2016 |
|
| Level of Evidence : |
|
| Physical stability : |
|
| Chemical stability : |
|
| Other methods : |
|
| Comments : |
|
List of drugs
 Levodopa/Carbidopa
|
 |
 |
 |
 |
1000/250 mg
Sinemet® |
| Glycerin |
10 mL |
| Distilled water |
10 mL |
| Citric acid anhydrous |
1 g |
|
22°C |
 |
| 10 |
 |
|
|
|
|
|
2000/500 mg
Sinemet® |
| Sodium benzoate |
400 mg |
| Aspartame |
200 mg |
| Citric acid anhydrous |
84 g |
| Distilled water |
400 mL |
| Sodium edetate |
40 mg |
|
22°C |
|
| 28 |
|
|
|
|
|
|
1000/250 mg
Sinemet® |
| Glycerin |
10 mL |
| Distilled water |
10 mL |
| Citric acid anhydrous |
1 g |
|
5°C |
|
| 35 |
|
|
|
|
|
|
2000/500 mg
Sinemet® |
| Sodium benzoate |
400 mg |
| Aspartame |
200 mg |
| Citric acid anhydrous |
84 g |
| Distilled water |
400 mL |
| Sodium edetate |
40 mg |
|
5°C |
|
| 35 |
|
|
|
|
|
