Last update :
19/11/2024
References   References 3923  
Type : Journal
Web link : http://www.ajhp.org/content/74/1/e64

Research teams : Johnson City - East Tennesse State University, Bill Gatton college of Pharmacy
Authors : Luu Y, Thigpen J, Brown S.D.
Title : Stability of sildenafil in combination with heparin and dopamine.
Reference : Am J Health-Syst Pharm ; 74, 1: e64-e71 2017

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
No comments for the degradation products

List of drugs
injectionDopamine hydrochloride Cardiotonic
Compatible 1,6 mg/ml + injectionSildenafil citrate 0,4 mg/ml + Glucose 5%
injectionHeparin sodium Anticoagulant
Compatible 1 UI/ml + injectionSildenafil citrate 0,4 mg/ml + Glucose 5%
injectionSildenafil citrate Vasodilator
Stability in solutions Glass Glucose 5% 0,4 mg/ml 20°C Light
30 Day
Stability in solutions Glass Glucose 5% 0,4 mg/ml 5°C Not specified
30 Day
Compatible 0,4 mg/ml + injectionDopamine hydrochloride 1,6 mg/ml + Glucose 5%
Compatible 0,4 mg/ml + injectionHeparin sodium 1 UI/ml + Glucose 5%

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