Last update :
19/11/2024
References   References 3891  
Type : Journal
Web link : http://www.cjhp-online.ca/index.php/cjhp/article/view/1437

Research teams : Toronto - Sunnybrook Health Sciences Center
Authors : Walker S.E, Law S, Perks W, Iazzetta J.
Title : Stability of Ertapenem 100 mg/mL in Manufacturer’s Glass Vials or Syringes at 4°C and 23°C
Reference : Can J Hosp Pharm ; 68, 2: 121-126. 2015

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
Degradation products detected but not quantified

List of drugs
injectionErtapenem Antibiotic
Factors which affect stability Temperature Increase Induces Degradation
Factors which affect stability Concentration Increase Induces Reduced stability
Stability in solutions Glass Sodium chloride 0,9% 100 mg/ml 23°C Protect from light
5 Hour
Stability in solutions Glass Sodium chloride 0,9% 100 mg/ml 4°C Protect from light
48 Hour
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 100 mg/ml 23°C Protect from light
5 Hour
conflicting data
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 100 mg/ml 4°C Protect from light
48 Hour
conflicting data

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