Last update :
03/05/2024
References   References 3842  
Type : Journal
Web link : http://www.ajhp.org/content/73/3/137.abstract

Research teams : Bethesda - National Institutes of Health Clinical Center
Authors : Lee J.H, Goldspiel B.R, Ryu S, Potti G.K.
Title : Stability of tacrolimus solutions in polyolefin containers.
Reference : Am J Health-Syst Pharm ; 73:137-142. 2016

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products not observed in real conditions
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point

List of drugs
InjectionTacrolimus Immunosuppressant
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 10 µg/ml 20-25°C Not specified
48 Hour
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 100 µg/ml 20-25°C Not specified
48 Hour
Stability in solutions Polyolefine Sodium chloride 0,9% 1 µg/ml 20-25°C Not specified
24 Hour
Stability in solutions Polyolefine Glucose 5% 1 µg/ml 20-25°C Not specified
48 Hour

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