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References   References 381  
Type : Journal
Research teams : Utrecht - Faculty of pharmacy, State university of Utrecht
Authors : Beijnen JH, Van Gijn R.
Title : Chemical stability of the cardioprotective agent ICRF-187 in infusion fluids.
Reference : J Parenter Sci Technol ; 47: 166-171. 1993
Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionDexrazoxane hydrochloride Cytoprotective
Factors which affect stability pH Increase Induces Precipitation
Factors which affect stability Concentration 10 mg / ml4°C Induces Precipitation
Stability in solutions Glass NaCl 0,9% or Glucose 5% 1 mg/ml 4°C Protect from light
24 Hour
Stability in solutions Glass NaCl 0,9% or Glucose 5% 1 & 10 mg/ml 22°C With or without light
6 Hour
Stability in solutions Glass NaCl 0,9% or Glucose 5% 10 mg/ml 4°C Protect from light
6 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1 mg/ml 4°C Protect from light
24 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1 & 10 mg/ml 22°C With or without light
6 Hour
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