Bibliographie - 381 - Stabilis 4.0

Last update :
29/10/2024

References

References 381

Type :

Journal

Research teams :

Utrecht - Faculty of pharmacy, State university of Utrecht

Authors :

Beijnen JH, Van Gijn R.

Title :

Chemical stability of the cardioprotective agent ICRF-187 in infusion fluids.

Reference :

J Parenter Sci Technol ; 47: 166-171. 1993

Level of Evidence :

Level of evidence B

AideBibliographie

Physical stability :

Visual examination

Chemical stability :

High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)

Stability defined as 90% of the initial concentration

Other methods :

PH measurement

Comments :

List of drugs

injection

Dexrazoxane hydrochloride

Cytoprotective

Factors which affect stability

pH

Increase

Induces

Precipitation

Factors which affect stability

Concentration

10 mg / ml4°C

Induces

Precipitation

Stability in solutions

Glass

NaCl 0,9% or Glucose 5%

1 mg/ml

4°C

Protect from light

24

Hour

Stability in solutions

Glass

NaCl 0,9% or Glucose 5%

1 & 10 mg/ml

22°C

With or without light

6

Hour

Stability in solutions

Glass

NaCl 0,9% or Glucose 5%

10 mg/ml

4°C

Protect from light

6

Hour

Stability in solutions

Polyvinyl chloride

NaCl 0,9% or Glucose 5%

1 mg/ml

4°C

Protect from light

24

Hour

Stability in solutions

Polyvinyl chloride

NaCl 0,9% or Glucose 5%

1 & 10 mg/ml

22°C

With or without light

6

Hour

Mentions Légales