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References   References 3780  
Type : Journal
Web link : http://ejhp.bmj.com/content/22/1/7.abstract
Research teams : Wuhan - Wuhan University, College of Pharmacy
Authors : Chen F, Peng L, Zhou B, Fang B, Yang Y.
Title : Stability of an epidural analgesic admixture containing butorphanol tartrate and ropivacaine hydrochloride
Reference : EJHP ;22:7-11 2015
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
InjectionButorphanol tartrate Analgesic
Compatible 0,05 mg/ml + InjectionRopivacain hydrochloride 1 & 2 mg/ml + Sodium chloride 0,9%
InjectionRopivacain hydrochloride Local anesthetic
Compatible 1 & 2 mg/ml + InjectionButorphanol tartrate 0,05 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polyolefine Sodium chloride 0,9% 25°C Protect from light
Injection Butorphanol tartrate 0.05 mg/ml
Injection Ropivacain hydrochloride 1 & 2 mg/ml
15 Day
Polyolefine Sodium chloride 0,9% 4°C Protect from light
Injection Butorphanol tartrate 0.05 mg/ml
Injection Ropivacain hydrochloride 1 & 2 mg/ml
15 Day
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