Last update :
03/05/2024
References   References 3717  
Type : Journal
Web link : http://www.ajhp.org/content/71/17/1480.abstract

Research teams : Hartford - Center for Anti-Infective Research and Development
Authors : Jain J.G, Sutherland C, Nicolau D.P, Kuti J.L.
Title : Stability of ertapenem 100 mg/mL in polypropylene syringes stored at 25, 4, and -20 °C.
Reference : Am J Health-Syst Pharm ; 71:1480-1484 2014

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
Stability indicating capability inadequately assessed
Method not shown but the article refers to a validated method
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied
No visual inspection
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
No comments for the degradation products

List of drugs
InjectionErtapenem Antibiotic
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 100 mg/ml -20°C Not specified
28 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 100 mg/ml 25°C Light
0.5 Hour
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 100 mg/ml 4°C Not specified
24 Hour
Conflicting data

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