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References   References 363  
Type : Journal
Research teams : Waukegan - Du pont Critical Care, Pharmaceutical Development Department
Authors : Karnatz NN, Wong J, Baaske DM, Johnson JH, Speicher ER, Herbranson DE.
Title : Stability of esmolol hydrochloride and sodium nitroprussiate in intravenous admixtures.
Reference : Am J Hosp Pharm ; 46: 101-104. 1989
Level of Evidence : 
Level of evidence A+
Physical stability : 
Turbidimetry Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionEsmolol hydrochloride Beta-blocker
Compatible 10 mg/ml + injectionNitroprusside sodium 0,2 mg/ml + Glucose 5%
injectionNitroprusside sodium Vasodilator
Compatible 0,2 mg/ml + injectionEsmolol hydrochloride 10 mg/ml + Glucose 5%
Stability of mixtures
Not specified Glucose 5% 15-30°C Protect from light
injection Esmolol hydrochloride 10 mg/ml
injection Nitroprusside sodium 0,2 mg/ml
24 Hour
  Mentions Légales