Last update :
28/04/2024
References   References 3622  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=3801

Research teams : Houston - Memorial Hermann, Texas Medical Center
Authors : Weeks Phillip A, Teng Yang, Wu Lei, Sun Mary, Yang Zhen, Chow Diana S-L.
Title : Chemical and Physical Compatibility of an Intravenous Solution of Epinephrine with Calcium Chloride.
Reference : Int J Pharm Compound ; 18, 2 : 152-158. 2014

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
Degradation products not observed in real conditions

List of drugs
InjectionCalcium chloride Electrolyte
Compatible 4 mg/ml + InjectionEpinephrine hydrochloride 32 µg/ml + Sodium chloride 0,9%
InjectionEpinephrine hydrochloride Sympathomimetic
Compatible 32 µg/ml + InjectionCalcium chloride 4 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Not specified Sodium chloride 0,9% 25°C With or without light
Injection Calcium chloride 4 mg/ml
Injection Epinephrine hydrochloride 32 µg/ml
26 Hour

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