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References   References 3610  
Type : Journal
Research teams : Houston - M.D.Anderson Cancer Center
Authors : Zhang, Y., Kawedia, J.D., Myers, A.L., McIntyre, C.M., Anderson, P.M., Kramer, M.A., Culotta, K.
Title : Physical and chemical stability of high-dose ifosfamide and mesna for prolonged 14-day continuous infusion.
Reference : J Oncol Pharm Practice ; 20, 1: 51-57. 2014
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
List of drugs
injectionIfosfamide Anticancer drug
Compatible 10 >> 30 mg/ml + injectionMesna 10 >> 30 mg/ml + Sodium chloride 0,9%
injectionMesna Cytoprotective
Compatible 10 >> 30 mg/ml + injectionIfosfamide 10 >> 30 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 20-25°C Light
injection Ifosfamide 20 mg/ml
injection Mesna 20 mg/ml
14 Day
Polyvinyl chloride Sodium chloride 0,9% 20-25°C Light
injection Ifosfamide 30 mg/ml
injection Mesna 30 mg/ml
14 Day
Polyvinyl chloride Sodium chloride 0,9% 20-25°C
injection Ifosfamide 10 mg/ml
injection Mesna 10 mg/ml
14 Day
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