Last update :
03/05/2024
References   References 3476  
Type : Journal

Research teams : Montreal - Faculté de pharmacie, Université de Montréal
Authors : Li M, Coursol C, Leclair G.
Title : Stability of cyclosporine diluted with 0.9% sodium chloride injection or 5% dextrose injection and stored in ethylene-vinyl acetate containers.
Reference : Am J Health-Syst Pharm ;70:1970-1972. 2013

Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
Degradation products not observed in real conditions
Method not shown but used to deposit authorization to market

List of drugs
InjectionCiclosporin Immunosuppressant
Stability in solutions Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 0,2 mg/ml 25°C Not specified
7 Day
Stability in solutions Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 2,5 mg/ml 25°C Not specified
14 Day

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