Last update :
19/11/2024
References   References 3386  
Type : Journal
Web link : https://doi.org/10.1016/j.ijpharm.2013.02.039

Research teams : Créteil - Henri Mondor University Hospital, Department of Pharmacy
Authors : Paul M, Vieillard V, Da Silva Lemos R, Escalup L, Astier A.
Title : Long-term physico-chemical stability of diluted trastuzumab.
Reference : Int J Pharm ; 448: 101-104. 2013

Level of Evidence : 
Level of evidence B+
Physical stability : 
Turbidimetry Protein: Dynamic Light Scattering Protein: Size Exclusion Chromatography 
Chemical stability : 
Protein: Peptide mapping
Protein: ionic chromatography
Protein: ultraviolet spectrometry and second derivative
Protein: intrared spectrometry and second derivative
Other methods : 
Comments : 
Protein: no biological methods

List of drugs
injectionTrastuzumab Anticancer drug
Stability in solutions Polyolefine Sodium chloride 0,9% 0,8 mg/ml 18-22°C Protect from light
180 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 0,8 mg/ml 2-8°C Protect from light
180 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 2,4 mg/ml 18-22°C Protect from light
180 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 2,4 mg/ml 2-8°C Protect from light
180 Day

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