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References   References 3381  
Type : Journal
Web link : http://ejhp.bmj.com/content/20/2/110.abstract
Research teams : Lausanne - University Hospital, Department of Pharmacy
Authors : Humbert-Delaloye V, Berger-Gryllaki M, Voirol P, Gattlen L, Pannatier A.
Title : In vitro compatibility of various cardioactive drugs during simulated Y-site administration.
Reference : EJHP ; 20:110-116. 2013
Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
List of drugs
InjectionAmiodarone hydrochloride Anti-arrhythmic
InjectionDobutamine hydrochloride Cardiotonic
Compatible 5 mg/ml + InjectionNorepinephrine bitartrate 0.06 mg/ml + Glucose 5%
InjectionDopamine hydrochloride Cardiotonic
Compatible 5 mg/ml + InjectionNitroprusside sodium 1.2 mg/ml + Glucose 5%
InjectionNitroprusside sodium Vasodilator
Factors which affect stability Storage Light Induces Degradation
Compatible 1.2 mg/ml + InjectionDopamine hydrochloride 5 mg/ml + Glucose 5%
Incompatible 1.2 mg/ml + InjectionSodium thiosulfate 10 mg/ml + Glucose 5%
InjectionNorepinephrine bitartrate Sympathomimetic
Compatible 0.06 mg/ml + InjectionDobutamine hydrochloride 5 mg/ml + Glucose 5%
InjectionSodium thiosulfate Antidote
Incompatible 10 mg/ml + InjectionNitroprusside sodium 1.2 mg/ml + Glucose 5%
Stability of mixtures
Glass Glucose 5% 22°C Protect from light
Injection Dobutamine hydrochloride 5 mg/ml
Injection Nitroprusside sodium 1,2 mg/ml
24 Hour
Glass Glucose 5% 22°C
Injection Dopamine hydrochloride 5 mg/ml
Injection Norepinephrine bitartrate 0,06 mg/ml
24 Hour
Glass Glucose 5% 22°C
Injection Dobutamine hydrochloride 5 mg/ml
Injection Norepinephrine bitartrate 0,06 mg/ml
24 Hour
Glass Glucose 5% 22°C
Injection Dobutamine hydrochloride 5 mg/ml
Injection Norepinephrine bitartrate 0,06 mg/ml
Injection Amiodarone hydrochloride 12,5 mg/ml
24 Hour
Polyethylene Glucose 5% 22°C Protect from light
Injection Dobutamine hydrochloride 5 mg/ml
Injection Nitroprusside sodium 1,2 mg/ml
24 Hour
Polyethylene Glucose 5% 22°C
Injection Dopamine hydrochloride 5 mg/ml
Injection Norepinephrine bitartrate 0,06 mg/ml
24 Hour
Polyethylene Glucose 5% 22°C
Injection Dobutamine hydrochloride 5 mg/ml
Injection Norepinephrine bitartrate 0,06 mg/ml
24 Hour
Polyethylene Glucose 5% 22°C
Injection Dobutamine hydrochloride 5 mg/ml
Injection Norepinephrine bitartrate 0,06 mg/ml
Injection Amiodarone hydrochloride 12,5 mg/ml
24 Hour
  Mentions Légales