Last update :
19/11/2024
References   References 332  
Type : Journal
Web link : https://doi.org/10.1177/106002809502901106

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Xu QA, Trissel LA, Fox JL.
Title : Compatibility of ondansetron hydrochloride with meperidine hydrochloride for combined administration.
Reference : Ann Pharmacotherapy ; 29: 1106-1109. 1995

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 

List of drugs
injectionOndansetron hydrochloride Antiemetic
Compatible 0.1 & 1 mg/ml + injectionPethidine hydrochloride 4 mg/ml + Sodium chloride 0,9%
injectionPethidine hydrochloride Analgesic
Compatible 4 mg/ml + injectionOndansetron hydrochloride 0.1 & 1 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 22°C Not specified
injection Pethidine hydrochloride 4 mg/ml
injection Ondansetron hydrochloride 0,1 & 1 mg/ml
31 Day
Polyvinyl chloride Sodium chloride 0,9% 32°C Not specified
injection Pethidine hydrochloride 4 mg/ml
injection Ondansetron hydrochloride 0,1 & 1 mg/ml
7 Day
Polyvinyl chloride Sodium chloride 0,9% 4°C Protect from light
injection Pethidine hydrochloride 4 mg/ml
injection Ondansetron hydrochloride 0,1 & 1 mg/ml
31 Day

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