Last update :
19/11/2024
References   References 3318  
Type : Journal
Web link : http://www.em-consulte.com/article/723718/article/stability-of-ready-to-use-temsirolimus-infusion-so

Research teams : Montpellier - Oncopharmacology Laboratory, Val D'Aurelle Cancer Center
Authors : Poujol S, Bressolle F, Solassol I, Pinguet F.
Title : Stability of ready-to-use temsirolimus infusion solution (100 mg/L) in polypropylene containers under different storage conditions.
Reference : Ann Pharm Fr ; 70, 3: 155-162. 2012

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
Other methods : 
Comments : 
Degradation products not observed in real conditions

List of drugs
injectionTemsirolimus Anticancer drug
Factors which affect stability Storage Light Induces Degradation
Factors which affect stability Temperature Increase Induces Degradation
Stability in solutions Polypropylene Sodium chloride 0,9% 0,1 mg/ml 20°C Protect from light
3 Day
Stability in solutions Polypropylene Sodium chloride 0,9% 0,1 mg/ml 4°C Protect from light
4 Day

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