Last update :
28/04/2024
References   References 3312  
Type : Journal
Web link : http://www.em-consulte.com/article/713024/long-term-stability-of-bevacizumab-repackaged-in-1
Icone.pdf
1221Ko

Research teams : Créteil - Henri Mondor University Hospital, Department of Pharmacy
Authors : Paul M, Vieillard V, Roumi E, Cauvin A, Despiau M.C, Laurent M, Astier A.
Title : Long-term stability of bevacizumab repackaged in 1 mL polypropylene syringes for intravitreal administration.
Reference : Ann Pharm Fr ; 70, 3: 139-154. 2012

Level of Evidence : 
Level of evidence B+
Physical stability : 
Turbidimetry Microscopic examination Protein: Dynamic Light Scattering Protein: Size Exclusion Chromatography Protein: Thermal Aggregation Curve 
Chemical stability : 
Protein: Peptide mapping
Protein: ionic chromatography
Protein: ultraviolet spectrometry and second derivative
Protein: intrared spectrometry and second derivative
Other methods : 
Comments : 
Protein: no biological methods

List of drugs
InjectionBevacizumab Anticancer drug
Stability in solutions Polypropylen Syringe None 25 mg/ml 4°C Protect from light
90 Day

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