Last update :
28/04/2024
References   References 33  
Type : Journal

Research teams : Saint Germain en Laye - CHI Poissy Saint Germain en Laye - Service Pharmacie
Authors : Baud-Camus F, Crauste-Manciet S, Klein E, Richard L, Brossard D.
Title : Stability of fluorouracil in polypropylene syringes and ethylene vinyl acetate infusion-pump reservoirs.
Reference : Am J Health-Syst Pharm ; 53: 1457-1458. 1996

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
Thin Layer Chromatography
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Degradation products not observed in real conditions

List of drugs
InjectionFluorouracil Anticancer drug
Stability in solutions Ethylene vinyl acetate Sodium chloride 0,9% 15 & 45 mg/ml 25°C Protect from light
3 Day
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 12 & 40 mg/ml 25°C Protect from light
3 Day

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