Last update :
28/04/2024
References   References 3289  
Type : Journal

Research teams : Bydgoszcz - Nicolaus Copernicus University Collegium Medicum
Authors : Kodym A, Hapka-Zmich D, Golab M, Gwizdala M.
Title : Stability of ceftazidime in 1% and 5% buffered eye drops determined by HPLC method.
Reference : Acta Pol Pharm ; 68, 1: 99-107. 2011

Level of Evidence : 
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement Measurement of osmolality 
Comments : 
Degradation products identified

List of drugs
Eye-dropsCeftazidime Antibiotic
Factors which affect stability Temperature Increase Induces Degradation
Factors which affect stability Concentration Increase Induces Reduced stability
Factors which affect stability Excipient Polyvinyl alcohol Induces Reduced stability
Factors which affect stability Excipient Borate Phenylmercuric Induces Reduced stability
Factors which affect stability Excipient ßphenylethylalcool Induces Reduced stability
Stability in solutions Glass Medicine bottle for injection 100 mg
Ceftazidime Biotum®
Borate Phenylmercuric 0,04% 250 mg
ßphenylethylalcool 40 mg
Citrate buffer pH 6,24>>9,21g
4°C Protect from light
24 Day
Stability in solutions Glass Medicine bottle for injection 500 mg
Ceftazidime Biotum®
Citrate buffer pH 6,64>>10g
4°C Protect from light
21 Day
Stability in solutions Glass Medicine bottle for injection 100 mg
Ceftazidime Biotum®
Citrate buffer pH 6,24>>10g
4°C Protect from light
27 Day
Stability in solutions Glass Medicine bottle for injection 500 mg
Ceftazidime Biotum®
Borate Phenylmercuric 0,04% 250 mg
ßphenylethylalcool 40 mg
Citrate buffer pH 6,64>>9,21g
4°C Protect from light
15 Day
Stability in solutions Glass Medicine bottle for injection 100 mg
Ceftazidime Biotum®
Polyvinyl alcohol ŋ = 43.2 mPas pH 5.51 4,950 g
Citrate buffer pH 6,10 >>4,950 g
4°C Protect from light
18 Day
Stability in solutions Glass Medicine bottle for injection 100 mg
Ceftazidime Biotum®
Polyvinyl alcohol ŋ = 43.2 mPas pH 5.51 4,805g
Borate Phenylmercuric 0,04% 250mg
ßphenylethylalcool 40mg
Citrate buffer pH 6,10 >>4,805g
4°C Protect from light
18 Day
Stability in solutions Glass Medicine bottle for injection 500 mg
Ceftazidime Biotum®
Polyvinyl alcohol ŋ = 43.2 mPas pH 5.51 4,75g
Citrate buffer pH 6,10 >>4,750g
4°C Protect from light
15 Day
Stability in solutions Glass Medicine bottle for injection 500 mg
Ceftazidime Biotum®
Polyvinyl alcohol ŋ = 43.2 mPas pH 5.51 4,605g
Borate Phenylmercuric 0,04% 250mg
ßphenylethylalcool 40mg
Citrate buffer pH 6,10 >>4,605g
4°C Protect from light
12 Day

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