Last update :
29/10/2024
References   References 3277  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=3412

Research teams : Madison - University of Wisconsin-Madison, School of Pharmacy
Authors : Yang Z, Cameron S, Paul H.
Title : Stability of Carboplatin, Paclitaxel, and Docetaxel with Acetyl-L-carnitine During Simulated Y-site Administration.
Reference : Int J Pharm Compound ; 16, 1 : 82-85. 2012

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
No comments for the degradation products

List of drugs
injectionAcetyl L-carnitine Various
injectionCarboplatin Anticancer drug
injectionDocetaxel Anticancer drug
injectionPaclitaxel Anticancer drug
Stability of mixtures
Glass Glucose 5% 25°C
injection Acetyl L-carnitine 15 mg/ml
injection Carboplatin 2 mg/ml
4 Hour
Glass Glucose 5% 25°C
injection Acetyl L-carnitine 15 mg/ml
injection Paclitaxel 0,6 mg/ml
4 Hour
Glass Glucose 5% 25°C
injection Acetyl L-carnitine 15 mg/ml
injection Docetaxel 0,37 mg/ml
4 Hour

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