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References   References 3275  
Type : Journal
Web link : http://www.ajhp.org/content/69/3/232.abstract
Research teams : Ghent - laboratory of Pharmaceutical technology, State University of Gent
Authors : D'Hondt M, Vangheluwe E, Van Dorpe S, Boonen J, Bauters T, Pelfrene B, Vandenbroucke J, Robays H, De Spiegeleer B
Title : Stability of extemporaneously prepared cytarabine, methotrexate sodium, and methylprednisolone sodium succinate
Reference : Am J Health-Syst Pharm ; 69: 232-240. 2012
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
Other methods : 
Comments : 
Degradation products identified and quantified
List of drugs
InjectionCytarabine Anticancer drug
InjectionMethotrexate sodium Anticancer drug
InjectionMethylprednisolone sodium succinate Anti-inflammatory
Stability of mixtures
Polypropylen Syringe None 5°C Protect from light
Injection Methylprednisolone sodium succinate 0,51 mg/ml
Injection Methotrexate sodium 1,54 mg/ml
Injection Cytarabine 3,85 mg/ml
12 Hour
  Mentions Légales