Last update :
29/10/2024
References   References 3182  
Type : Journal
Web link : https://doi.org/10.1691/ph.2011.0214

Research teams : Bydgoszcz - Nicolaus Copernicus University Collegium Medicum
Authors : Kodym A, PawLowska M, Ruminski JK, Bartosinska A, Kieliba A.
Title : Stability of cefepime in eye drops.
Reference : Pharmazie ; 66, 1: 17-23. 2011

Level of Evidence : 
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Measurement of osmolality PH measurement 
Comments : 

List of drugs
Eye-dropsCefepime dihydrochloride Antibiotic
Factors which affect stability Temperature 20°C Induces Reduced stability
Stability in solutions Not specified Commercial Drug product 1,725 g
Maxipime®
Water for injection 98,3 g
4°C Protect from light
24 Day
Stability in solutions Not specified Commercial Drug product 1,725 g
Maxipime®
Citrate buffer pH 6.25 - 302 mOsmol/L 98,3 g
4°C Protect from light
27 Day
Stability in solutions Not specified Commercial Drug product 1,725 g
Maxipime®
Borate Phenylmercuric 0,04% 2,5 g
ßphenylethylalcool 0,4 g
Citrate buffer pH 6.25 - 302 mOsmol/L 95,4 g
4°C Protect from light
27 Day
Stability in solutions Not specified Commercial Drug product 1,725 g
Maxipime®
polyvinyl alcohol ŋ = 42.3 mPas pH 4.48 49,13 g
Citrate buffer pH 6.05 - 586 mOsmol/L 49,13 g
4°C Protect from light
21 Day
Stability in solutions Not specified Commercial Drug product 1,725 g
Maxipime®
polyvinyl alcohol ŋ = 42.3 mPas pH 4.48 47,70 g
Borate Phenylmercuric 0,04% 2,5 g
ßphenylethylalcool 0,4 g
Citrate buffer pH 6.05 - 586 mOsmol/L 47,70 g g
4°C Protect from light
21 Day

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