Last update :
28/04/2024
References   References 3083  
Type : Journal
Web link : ; 66: 1478-1483.

Research teams : Parkville - Monash University, Victorian College of Pharmacy
Authors : Al-Badriyeh D, Li J, Stewart K, Kong DCM, Leung L, Davies GE, Robert Fullinfaw R.
Title : Stability of extemporaneously prepared voriconazole ophthalmic solution
Reference : Am J Health-Syst Pharm ; 66: 1478-1483. 2009

Level of Evidence : 
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
Eye-dropsVoriconazole Antifungal
Stability in solutions Polyethylene Medicine bottle for injection 30 mg
Vfend®
Benzalkonium chloride 0.3 mg
Water for injection >> 3 ml
2-8°C Protect from light
98 Day
Stability in solutions Polyethylene Medicine bottle for injection 60 mg
Vfend®
Benzalkonium chloride 0.3 mg
Water for injection >> 3 ml
2-8°C Protect from light
112 Day
Stability in solutions Polyethylene Medicine bottle for injection 60 mg
Vfend®
Benzalkonium chloride 0.3 mg
Water for injection >> 3 ml
25°C Protect from light
112 Day
Stability in solutions Polyethylene Medicine bottle for injection 60 mg
Vfend®
Benzalkonium chloride 0.3 mg
Water for injection >> 3 ml
40°C Protect from light
56 Day

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