Last update :
28/04/2024
References   References 3001  
Type : Journal
Web link : http://www.em-consulte.com/article/959984/article/long-term-stability-of-acyclovir-in-0-9-nacl-infus

Research teams : Mont Godinne - Drug Stability Research Group (DSRG) - CHU UCL NAMUR, site de Godinne
Authors : Dewulf J, Galanti L, Godet M, Gillet P, Jamart J, Hecq JD.
Title : Long-term stability of aciclovir in 0.9% NaCl infusion polyolefin bags at 2-8°C after freeze-thaw treatment: A generic product versus the brand name.
Reference : Ann Pharm Fr ; 73: 108-113. 2015

Level of Evidence : 
Level of evidence D
Physical stability : 
Turbidimetry Microscopic examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
PH measurement 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
Degradation products not observed in real conditions

List of drugs
InjectionAciclovir sodium Antiviral
Stability in solutions Polyolefine Sodium chloride 0,9% 5 mg/ml -20°C Protect from light
90 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 5 mg/ml 2-8°C Not specified
21 Day

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