Last update :
28/04/2024
References   References 30  
Type : Journal

Research teams : Travis AFB - David Grant Medical Center, Travis Air Force bas
Authors : Hagan RL, Mallett MS, Fox JL.
Title : Stability of ondansetron hydrochloride and dexamethasone sodium phosphate in infusion bags and syringes for 32 days.
Reference : Am J Health-Syst Pharm ; 53: 1431-1435. 1996

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 0.2 & 0.4 mg/ml + InjectionOndansetron hydrochloride 0.1 >> 0.64 mg/ml + NaCl 0,9% or Glucose 5%
InjectionOndansetron hydrochloride Antiemetic
Compatible 0.1 >> 0.64 mg/ml + InjectionDexamethasone sodium phosphate 0.2 & 0.4 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 2-6°C Protect from light
Injection Ondansetron hydrochloride 0,1 >> 0,4 mg/ml
Injection Dexamethasone sodium phosphate 0,02 & 0,4 mg/ml
30 Day
Polyvinyl chloride Sodium chloride 0,9% 2-6°C Protect from light
Injection Ondansetron hydrochloride 0,1 >> 0,64 mg/ml
Injection Dexamethasone sodium phosphate 0,2 & 0,4 mg/ml
30 Day
Polyvinyl chloride Sodium chloride 0,9% 22°C-23°C Protect from light
Injection Dexamethasone sodium phosphate 0.2 & 0.4 mg/ml
Injection Ondansetron hydrochloride 0,1 >> 0,4 mg/ml
48 Hour
Polyvinyl chloride Sodium chloride 0,9% 22°C-23°C Protect from light
Injection Ondansetron hydrochloride 0,1 >> 0,64 mg/ml
Injection Dexamethasone sodium phosphate 0,2 & 0,4 mg/ml
48 Hour

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