| Type : |
Journal |
|
| Research teams : |
Rochester - University of Rochester Medical Center, Department of Pharmacy |
| Authors : |
Dentinger PJ, Swenson CF, Anaizi NH. |
| Title : |
Stability of amphotericin B in an extemporaneously compounded oral suspension. |
| Reference : |
Am J Health-Syst Pharm ; 58: 1021-1024. 2001 |
|
| Level of Evidence : |
|
| Physical stability : |
|
| Chemical stability : |
|
| Other methods : |
|
| Comments : |
|
List of drugs
 Amphotericin B
|
 |
 |
 |
 |
30 g
Amphotericin B |
| Na2HPO4 |
4.77 g |
| NaH2PO4 |
2.88 g |
| Sodium benzoate |
300 mg |
| Sodium metabisulfite |
450 mg |
| Citric acid |
2.25 g |
| Carboxymethylcellulose |
1% 37.5 ml |
| Methylparaben |
300 mg |
| Propylparaben |
60 mg |
| Cherry flavor |
1.2 ml |
| Propylene glycol |
3 ml |
| Citric acid |
>> pH 4.3 |
| Purified water |
>> 300 ml |
|
22-25°C |
 |
| 93 |
 |
|
|
|
|
